The effects of drought on physiology of Tomato (Lycopersicon esculentum Mill.) cv., Farida grown in potswere studied. Drought stress was done by irrigating the plants with 80, 60 and 40% of water needed to reach soil potcapacity. Nutrients concentrations of the studied tomatoes grown in pots under different irrigation treatments variedaccording to water stress levels. The effect of water stress treatments on total chlorophyll, chlorophyll a, chlorophyll band carotenoids resulted in significant increase with treatment 80% water deficit, then significant decrease inaccumulation of pigments in response to water stress under 40 and 60% water deficit. All water stress treatments hadhighly significant effect on increasing accumulation of proline content. Drought stress induced different changes in theanti-oxidative enzyme activities, whereas, Ascorpate peroxidase and Catalase increased significantly with water stressfrom 0.58 and 140.7 Ug−1 FW in control to 4.08 and 414.9 Ug−1 FW in T4, respectively. In contrary, superoxidedismutase decreased significantly with water stress from 42.36 in T1, to 31.32, 33.54 and 31.51 in T2, T3 and T4,respectively. The results indicate that irrigation treatment with 80% of pot capacity (T2) was more effective than T3 andT4 from the viewpoint of more efficient water use, which would help to minimize drought damage and keep healthyplants in the same time saving irrigation water by 20%.